TOKIWA PHYTOCHEMICAL CO., LTD. Announces the Latest Clinical Study on the Benefits of VENETRON® on Menstrual Well-being

TOKIWA PHYTOCHEMICAL CO., LTD. (hereinafter “Tokiwa”), Japan, is excited to announce the publication of the latest research on VENETRON ®, a rafuma leaves extract. The study, titled "Effect of Apocynum venetum Leaf Extract (VENETRON®) on Unidentified Complaints Relating to Menstruation in Healthy Female Subjects – A Randomized, Double-blind, Placebo-controlled Parallel-group Comparison Study” is featured in the prestigious November 2023 issue of Japanese Pharmacology & Therapeutics (Vol. 51, No. 11, pages 1685-96).

This research aimed to assess the efficacy of VENETRON® in addressing both psychological and physical complaint associated with menstruation, conducted on healthy women experiencing complaints related to menstruation. The study employed a randomized, double-blind, and placebo-controlled methodology. Evaluation of 8 crucial subscales, including pain, water retention, autonomic nervous system, negative emotion, concentration, behavior change, mood uplift, and control, was carried out using Menstrual Distress Questionnaire (MDQ) throughout the menstrual cycle.

The MDQ results demonstrated that VENETRON® is remarkably effective in alleviating both psychological and physical complaint occurring BEFORE and DURING menstruation. Considering VENETRON® is one of Tokiwa’s representative products aimed at sleep quality improvement, it was also evaluated in women with complaints of menstruation by the Oguri-Shirakawa-Azumi Sleep Inventory for Middle-age and Aged version (OSA-MA). The result indicated that VENETRON® improves the sleep quality. This outcome serves as additional validation that VENETRON® not only enhances sleep quality for the general population but also extends its benefits to women with menstruation-related complaints.

These findings underscore the positive impact of VENETRON® as a non-hormonal menstrual support ingredient on overall menstrual well-being. Beyond its primary focus, this research contributes to advancing the understanding and addressing concerns related to women's health, paving the way for new avenues of research and development in this crucial area.

About TOKIWA PHYTOCHEMICAL CO., LTD.

Established in 1949 in Chiba, Japan, Tokiwa made history as the first Japanese company devoted to the intricate field of phytochemistry. Distinguished for its prolific manufacturing of diverse plant extracts and relentless exploration of their therapeutic potential, Tokiwa is now set to embark on an exciting journey of business expansion. With a profound commitment to enhancing human health, the company is poised to make significant contributions to the well-being of individuals worldwide.

For more information, please visit: https://www.tokiwaph.co.jp/en/